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Product Name:Crospovidone
INCI Name:Insoluble PVP
Pharmacopeia Name:Crospovidone
CAS NO.: 9003-39-8
Formula: (C6H9NO)n
Pharmaceutical Excipient Crospovidone is a crosslinked PVP,insoluble PVP,it is hygroscopic,insoluble in water and all other common solvents,but it swells rapidly in aqueous solutbition without any gel froms.Its; classified as Crospovidone Type A and Type B according to the different particle size.
Key Technical Parameters:
| Product |
Crospovidone Type A |
Crospovidone Type B |
| Appearance |
White or yellowish-white powder or flakes |
| Identifications |
A.Infrared Absorption |
| B.No blue color develops. |
| C.A Suspension is formed and no clear solution is obtained within 15 min. |
| D.Majority of particles are in the range 50 ~300 μm is type A,majority of particles are in the range 5~50 μm |
| Solubility |
Practically insoluble in water,in alcohol and in methylene chloride |
| Water- soluble substances |
1.0% max |
1.0% max |
| pH((1% in water) |
5.0 –8.0 |
5.0 –8.0 |
| Loss on Drying |
5.0% max. |
5.0% max. |
| Sulphated Ash |
0.1% max. |
0.1% max. |
| Nitrogen content |
11.0 -12.8 % |
11.0 -12.8 % |
| Impurity A |
10 ppm max. |
10 ppm max. |
| Peroxide(As H2O2) |
400 ppm max. |
1000 ppm max. |
| Heavy Metals |
10 ppm max. |
10 ppm max. |
Applications:
Crospovidone are widely used as 1)Disintergrating agent,2)Stabilizer for suspension,3)Moisture Absorbent, 4)Complextant of Polyphenols and Tannin for the extract formulations.
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Food Grade PVPP is a crosslinked PVP,insoluble,it is hygroscopic,insoluble in water and all other common solvents,but it swells rapidly in aqueous solutbition without any gel froms.
Key Technical Parameters:
| Product |
PVPP (One Way) |
PVPP(Regenerate) |
| Appearance |
White to off-white,hygroscopic,free-flowing powder |
| Solubility |
Insoluble in water and other common solvents. |
| Odour of the suspension |
Faint,Typical |
| Nitrogen |
11.0-12.8% |
11.0-12.8% |
| Heavy metals(As Pb) |
10ppm max. |
10ppm max. |
| Lead |
2 ppm max. |
2 ppm max. |
| Arsenic |
2 ppm max. |
2 ppm max. |
| pH(1% in Water Suspension) |
5.0-8.0 |
5.0-8.0 |
| Sulphated Ash |
0.4% max. |
0.4% max. |
| Water soluble substances |
0.5% max. |
0.5% max. |
| Solubility in Acetic Acid/Ethnol |
1.0% max. |
1.0% max. |
| Peroxides |
400 ppm max. |
400 ppm max. |
| N,N-Divinylimidazolidione |
2ppm max. |
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